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A recent case study has shown a possible increase in the plasma level of valproate when co-administered with isoniazid. Plateau levels of around 100-150 pg/mL (Abraham, 1978; Thorneycroft et al. The more common side effect include: constipation, diarrhoea, abdominal pain, nausea, headache and dizziness. Information for Healthcare Professionals: Concomitant Use of Ibuprofen and Aspirin". For indications where therapeutic drug monitoring is appropriate, monitor everolimus trough concentrations and adjust the dose of everolimus accordingly. The serum concentration of Methoxyflurane can be increased when it is combined with Fusidic Acid.