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Methotrexate: Renal tubular transport of methotrexate may be inhibited by concomitant administration of ciprofloxacin, potentially leading to increased plasma levels of methotrexate. No liquid is needed to take the orally disintegrating tablet. Their dopamine and serotonin levels were then measured, which showed that there were no observable decreases in both of these hormones. Mesalazine may increase the neuroexcitatory activities of Piromidic acid. Trandolapril: (Moderate) In the low-renin or volume-dependent hypertensive patient, prostaglandins play an important role in the hypotensive effects of ACE inhibitors. The serum concentration of Cisapride can be increased when it is combined with Butenafine.