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Respiratory tract infections ( 1. Having too little thyroxine or too much thyroxine can cause health problems. If you experience any of the following symptoms, stop taking metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizziness; lightheadedness; fast or slow heartbeat; flushing of the skin; muscle pain; or feeling cold, especially in your hands or feet. The risk or severity of adverse effects can be increased when Mefenamic acid is combined with Ramipril. Aspirin may be harmful to an unborn baby's heart, and may also reduce birth weight or have other dangerous effects. What are cold sores, chickenpox, shingles, and genital herpes?