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Due to the effects of gemfibrozil on sulfonylurea metabolic pathways, an increase in sulfonylurea exposure may occur. Vitamin K is needed to make clotting factors and prevent bleeding. Proteases, being themselves proteins, are cleaved by other protease molecules, sometimes of the same variety. The risk or severity of adverse effects can be increased when Diclofenamide is combined with Terazosin. They may be taken on an empty stomach or with meals. The metabolism of Imipramine can be increased when combined with Hexobarbital.