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Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1–98. Eq/L and 1 mEq/L is the usual range for maintenance treatment with immediate-release formulations. Close monitoring of blood glucose levels is advised for such patients. San peoples across Southern Africa. However, some bacterial cells have the enzyme β-lactamase, which hydrolyzes the beta-lactam ring, rendering the drug inactive. If serotonin syndrome occurs, all serotonergic agents should be discontinued and appropriate medical treatment should be implemented.