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This medication causes little nausea. Transient thrombocytopenia, leukopenia, neutropenia, prolongation in prothrombin time, elevated LDH, pancytopenia, agranulocytosis, and eosinophilia. Exposure of drugs metabolized by CYP2D6 such as ivermectin may be increased when co-administered with mirabegron. The risk or severity of adverse effects can be increased when Paricalcitol is combined with Digoxin. In many patients with heart failure who have no symptoms, RENITEC may help to stop the heart muscle from getting weaker. The risk or severity of adverse effects can be increased when Ticlopidine is combined with Atorvastatin.