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These changes are usually temporary. Increase daily dose of rifabutin by 50%. The serum concentration of Prednisolone can be increased when it is combined with Ranolazine. The risk or severity of adverse effects can be increased when Diflunisal is combined with Prednisone. This is less than 2% of the maternal weight-adjusted dose (7. Trimethoprim also inhibits both OCT2 and the hepatic isoenzyme CYP2C8.