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The risk or severity of adverse effects can be increased when Oxymorphone is combined with Lamotrigine. If you start on a low-salt diet, tell your doctor. This is not a miracle drug because there are none. Symptoms: may cause hypotension, renal failure, convulsions, gastrointestinal irritation or respiratory depression. Hypothyroidism usually occurs in middle-aged and older dogs although the condition will sometimes be seen in younger dogs of the larger breeds. Cadila Healthcare Ltd.