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Patients are also required to participate in the iPledge online program. Keep this leaflet with your medicine. The doctor may recommend that you take an over-the-counter pain reliever, such as the nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen (Advil, Motrin IB, others) or naproxen (Aleve, others), to help ease painful menstrual cramps. It does not take the place of talking with your doctor or pharmacist. The metabolism of Pioglitazone can be decreased when combined with Fosamprenavir. Azathioprine or 6-mercaptopurine.