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For best results, keep using the medication as directed, even if you feel fine. Recurrent OPC is common, affecting as many as 50% of patients ( 197). The metabolism of Ondansetron can be decreased when combined with Cimetidine. Adverse events attributable to buspirone may be more likely during concomitant administration with either diltiazem or verapamil. Adverse reactions reported at a frequency < 1% included rash, edema, and secondary infection. The metabolism of Dienogest can be decreased when combined with Venlafaxine.