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The metabolism of Dexmethylphenidate can be decreased when combined with Ropinirole. Unfortunately, EMSAM was not specifically evaluated for these depressive subtypes in the original clinical trials and reports (a recent post hoc analysis on atypical depression will be presented in the section “Equally effective in atypical and non-atypical depression”). Amiloride; Hydrochlorothiazide, HCTZ: (Moderate) Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the natriuretic effect of diuretics in some patients. Nebivolol may increase the bradycardic activities of Crizotinib. Phenytoin: Because Accutane may cause bone loss and phenytoin may lead to low bone mineral density, doctors should monitor patients who take these drugs together. This is followed by formation of a comedone and, eventually, inflammatory lesions.