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Without proteases the intestinal lining would not be able to digest proteins, causing serious consequences to your health. The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Clarithromycin resulting in a loss in efficacy. Talk to your doctor if you have concerns about fertility. The risk or severity of adverse effects can be increased when Clomipramine is combined with Sulpiride. Blocking only the peripheral dilator (beta) action of epinephrine with propranolol leaves its constrictor (alpha) action unopposed. Prednisolone has occasionally been linked to problems in the first 12 weeks of pregnancy.