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The risk or severity of adverse effects can be increased when Sufentanil is combined with Doxazosin. The metabolism of Dutasteride can be decreased when combined with Venlafaxine. The metabolism of Propranolol can be decreased when combined with Armodafinil. The risk or severity of adverse effects can be increased when Promethazine is combined with Sertraline. The metabolism of Imipramine can be decreased when combined with Darifenacin. Children aged 6 years and older can take it, but only to treat high blood pressure.