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Nausea and vomiting: If you have these symptoms while taking this drug, you may have too much theophylline in your body. Avoid wearing underwear that is tight-fitting or made from synthetic materials (for example, rayon or nylon). This drug may build up and cause more side effects in people with severe kidney disease. John's wort ( Hypericum perforatum) or St. A recent “kettling” incident in the Midwest city of St. Betamethasone was approved for medical use in the United States in 1961.