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Feeling anxious or restless. A: http://Effexor (venlafaxine) is a medication that is used to treat depression. The metabolism of Diltiazem can be decreased when combined with Clemastine. Alendronate can cause serious problems in the stomach or esophagus. ACTOS can cause your body to keep extra fluid (fluid retention), which leads to swelling (edema) and weight gain. In patients with long QT syndrome, cardiac disease, or patients taking other QT-prolonging medications, this can increase risk for life-threatening arrhythmias.